Prostatic Intraepithelial Neoplasia: Will It Help Doctors Pinpoint Early Prostate Cancer?
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چکیده
منابع مشابه
Chemopreventive Target for Prostate Cancer: Prostatic Intraepithelial Neoplasia
Prostate cancer is one of the most frequently diagnosed malignancies among the male population and the second common cancer-related death worldwide after lung cancer (Jemal et al., 2010). It is estimated that 30% of male older than 50 years are harboring microscopic transformation of adenocarcinoma within the prostate gland. Because of the dramatic rise in the incidence of prostate cancer with ...
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It was in 1987 that McNeal and Bostwick first described intraductal dysplasia during a whole-mount pathologic investigation of 100 prostates without cancer and 100 with cancer that were diagnosed in the pre–prostate-specific antigen era. They found foci of dysplasia in 82% of the prostates harboring cancer compared with 43% in those without cancer. Interestingly, both the grade and volume of dy...
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Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. Telomerase activation has been seen in many immor tal cell lines and cancers. Telomerase activity was analyzed in prostate carcinoma; in coexistent prostatic intraepithelial neoplasia (PIN), benign prostatahyperplasia (BPH), atrophy and normal tissue; and in benign prostate glands. Telomerase activity was dete...
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Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. Telomerase activation has been seen in many immortal cell lines and cancers. Telomerase activity was analyzed in prostate carcinoma; in coexistent prostatic intraepithelial neoplasia (PIN), benign prostatic hyperplasia (BPH), atrophy and normal tissue; and in benign prostate glands. Telomerase activity was det...
متن کاملHigh-grade prostatic intraepithelial neoplasia of the prostate: the precursor lesion of prostate cancer.
High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma. Correct morphologic identification of HGPIN and an understanding of how this diagnosis affects clinical management in the research setting are necessary as HGPIN is a premalignant lesion with many genetic alterations similar to prostate cancer, but is not yet invasive...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1996
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/88.15.1023